No, for security reasons it´s not possible to upload the whole database.
What we usually do is export the db, do draws and everything in an local/network db and synchronize/upload draws, draw records, results and timetable. For that you have a panel in the software with the respective functions.
If you create the draws online and then syncronize it will not overwrite the online version of the draws. You would have to -as you wrote- first connect to the online database and delete everything you need to replace (usually only draws). Draw records will be created locally anyway because during the tournament we recommend NOT to work directly on the online database.